CISH HER2/CEN 17 Dual detection kit is designed for the simultaneous detection of the HER2 gene and the centromere of the chromosome 17 in tissue or cell samples fixed in buffered formalin and embedded in paraffin. The HER2 gene (also known as ErbB2 and NEU) is located in chromosomal region 17q12 and encodes the receptor of the protein kinase erbB-2, also known as cell growth factor p185.

The HER2 proto-oncogene amplification is observed in approximately 20% of breast cancer and has been correlated with poor prognosis. Its determination has been established as mandatory for the treatment of patients with Herceptin, the humanized monoclonal antibody capable of blocking this receptor and for which similar results have been obtained in other malignancies such as ovarian, stomach and salivary gland carcinomas.