Description

CD34, also known as gp105-120, is a type I monomeric sialomucin-like glycophosphoprotein
with an approximate molecular weight of 105-120 kD. Selectively expressed on the majority of
hematopoietic stem/progenitor cells, bone marrow stromal cells, capillary endothelial cells,
embryonic fibroblasts, and some nervous tissue, CD34 is a commonly used marker to identify
human hematopoietic stem/progenitor cells. According to the differential sensitivity to enzymatic
cleavage, four groups of epitopes of CD34 have been described. CD34 mediates cell adhesion
and lymphocytes homing through binding to L-selectin and E-selectin ligands.