Description

CD4, also known as T4, is a 55 kD single-chain type I transmembrane glycoprotein expressed
on most thymocytes, a subset of T cells, and monocytes/macrophages. CD4, a member of the
Ig superfamily, recognizes antigens associated with MHC class II molecules, and participates in
cell-cell interactions, thymic differentiation, and signal transduction. CD4 acts as a primary
receptor for HIV, binding to HIV gp120. CD4 has also been shown to interact with IL-16.